This work is an attempt to redefine the notion of homeostasis, from a philosophical perspective, in order to make it useful for the ongoing investigations about organisms and systems in the fields of biology, physiology, immunology, philosophy, among others. In the first part I run a historical and philosophical analysis of the term, From Claude Bernard to Systems Biology; and in the second part I’ll expose my own definition of homeostasis and some of the implications it might have in the actual debates about organism, on one hand, and on the definitions of health and disease, in the other. My hypothesis aims at demonstrating how compulsory it is such a redefinition, and try to offer an alternative one, which might be useful both from a theoretical and from a practical perspective.